Enantioselective cyanation via radical-mediated C–C single bond cleavage for synthesis of chiral dinitriles
Ring-opening reaction via selective cleavage of C–C bond is a powerful strategy to increase molecular complexity. Here the authors present the facile synthesis of chiral 1,5- and 1,6-dinitriles via the radical-mediated ring-opening and enantioselective cyanation of cycloketone oxime esters.
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| Autores principales: | , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Nature Portfolio
2019-11-01
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| Colección: | Nature Communications |
| Acceso en línea: | https://doi.org/10.1038/s41467-019-13369-x |
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