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Prostate fibroblasts and prostate cancer associated fibroblasts exhibit different metabolic, matrix degradation and PD-L1 expression responses to hypoxia

Fibroblasts are versatile cells that play a major role in wound healing by synthesizing and remodeling the extracellular matrix (ECM). In cancers, fibroblasts play an expanded role in tumor progression and dissemination, immunosuppression, and metabolic support of cancer cells. In prostate cancer (P...

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Principais autores: Jesus Pacheco-Torres, Raj Kumar Sharma, Yelena Mironchik, Flonne Wildes, W. Nathaniel Brennen, Dmitri Artemov, Balaji Krishnamachary, Zaver M. Bhujwalla
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2024-03-01
coleção:Frontiers in Molecular Biosciences
Assuntos:
fibroblast
hypoxia
metabolism
prostate cancer
cancer associated fibroblast
PD-L1
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fmolb.2024.1354076/full
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