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CCR5 drives NK cell–associated airway damage in pulmonary ischemia-reperfusion injury

Primary graft dysfunction (PGD) limits clinical benefit after lung transplantation, a life-prolonging therapy for patients with end-stage disease. PGD is the clinical syndrome resulting from pulmonary ischemia-reperfusion injury (IRI), driven by innate immune inflammation. We recently demonstrated a...

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Principais autores: Jesse Santos, Ping Wang, Avishai Shemesh, Fengchun Liu, Tasha Tsao, Oscar A. Aguilar, Simon J. Cleary, Jonathan P. Singer, Ying Gao, Steven R. Hays, Jeffrey A. Golden, Lorriana Leard, Mary Ellen Kleinhenz, Nicholas A. Kolaitis, Rupal Shah, Aida Venado, Jasleen Kukreja, S. Sam Weigt, John A. Belperio, Lewis L. Lanier, Mark R. Looney, John R. Greenland, Daniel R. Calabrese
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical investigation 2023-11-01
Serier:JCI Insight
Fag:
Pulmonology
Transplantation
Online adgang:https://doi.org/10.1172/jci.insight.173716
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