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Influence of GABA(A) receptor α subunit isoforms on the benzodiazepine binding site.

Classical benzodiazepines, such as diazepam, interact with α(x)β(2)γ(2) GABA(A) receptors, x = 1, 2, 3, 5 and modulate their function. Modulation of different receptor isoforms probably results in selective behavioural effects as sedation and anxiolysis. Knowledge of differences in the structure of...

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Autores principales: Benjamin P Lüscher, Roland Baur, Maurice Goeldner, Erwin Sigel
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science (PLoS) 2012-01-01
Colección:PLoS ONE
Acceso en línea:http://europepmc.org/articles/PMC3407089?pdf=render
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