Macrophage-derived exosomal microRNA-501-3p promotes progression of pancreatic ductal adenocarcinoma through the TGFBR3-mediated TGF-β signaling pathway

Abstract Background Exosomes from cancer cells or immune cells, carrying bio-macromolecules or microRNAs (miRNAs), participate in tumor pathogenesis and progression by modulating microenvironment. Our study aims to investigate the role of these microRNA-501-3p (miR-501-3p) containing exosomes derive...

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Detalhes bibliográficos

Principais autores:	Zi Yin, Tingting Ma, Bowen Huang, Lehang Lin, Yu Zhou, Jinhai Yan, Yiping Zou, Sheng Chen
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2019-07-01
coleção:	Journal of Experimental & Clinical Cancer Research
Assuntos:	Pancreatic ductal adenocarcinoma Exosome M2 macrophage MicroRNA-501-3p TGFBR3 TGF-β signaling pathway
Acesso em linha:	http://link.springer.com/article/10.1186/s13046-019-1313-x
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