PTPN2 inhibition unleashes response to STING agonism in head and neck squamous cell cancer

Abstract cGAS-STING signaling can promote antitumor immunity, and tumor cell STING is suppressed in a variety of cancer subtypes that resist immune checkpoint blockade. Although STING agonists have failed clinical trials, precision approaches targeting restoration of tumor cell STING expression have...

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Huvudupphov:	Zehua Li, Cong Fu, Kartik Sehgal, Ann Marie Egloff, Tran C. Thai, Omar Avila Monge, Cun Lan Chuong, Yaiza Senent, Maia Shea Lineberry, Benjamin K. Eschle, Koji Haratani, Elena V. Ivanova, Marco Campisi, Navin R. Mahadevan, John D. Quadarella, Patrick C. Gedeon, Jonathan D. Schoenfeld, Michihisa Kono, Caroline G. Fahey, Chayapatou Chayawatto, Kenneth Ngo, Cloud P. Paweletz, Prafulla C. Gokhale, Robert T. Manguso, Ravindra Uppaluri, David A. Barbie
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Nature Portfolio 2026-05-01
Serie:	Nature Communications
Länkar:	https://doi.org/10.1038/s41467-026-72372-1
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