Large-Volume Intrathecal Administrations: Impact on CSF Pressure and Safety Implications

The increasing number of studies demonstrates the high potency of the intrathecal (IT) route for the delivery of biopharmaceuticals to the central nervous system (CNS). Our earlier data exhibited that both the infused volume and the infusion rate can regulate the initial disposition of the administe...

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Detalhes bibliográficos

Principais autores:	Vasily Belov, Janine Appleton, Stepan Levin, Pilar Giffenig, Beata Durcanova, Mikhail Papisov
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2021-04-01
coleção:	Frontiers in Neuroscience
Assuntos:	cerebrospinal fluid intracranial pressure intrathecal delivery macromolecules central nervous system craniospinal compliance
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fnins.2021.604197/full
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