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P-glycoprotein inhibitors improve effective dose and time of pregabalin to inhibit intermittent cold stress-induced central pain

Pregabalin (PGB) is a valuable therapeutic drug against chronic pain. Here we attempted to perform the combinatorial drug therapy with P-glycoprotein (P-gp) inhibitors to lower therapeutic dosage of PGB in the intermittent cold stress-induced fibromyalgia-like pain model. Single intracerebroventricu...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Takehiro Mukae, Wakako Fujita, Hiroshi Ueda
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2016-05-01
Schriftenreihe:Journal of Pharmacological Sciences
Schlagworte:
Pregabalin
Fibromyalgia
P-glycoprotein
Online-Zugang:http://www.sciencedirect.com/science/article/pii/S1347861316000037
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