Isolation of allele-specific, receptor-binding-defective low density lipoproteins from familial defective apolipoprotein B-100 subjects.

Familial defective apolipoprotein B-100 (FDB) is a genetic disorder apparently caused by a single amino acid substitution (Arg3500–>Gln) that disrupts the binding of low density lipoproteins (LDL) to the LDL receptor. The plasma of FDB heterozygotes contains a mixture of normal LDL and LDL that is d...

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Autori principali:	K S Arnold, M E Balestra, R M Krauss, L K Curtiss, S G Young, T L Innerarity
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 1994-08-01
Serie:	Journal of Lipid Research
Accesso online:	http://www.sciencedirect.com/science/article/pii/S0022227520400884
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