BET degraders reveal BRD4 disruption of 7SK and P-TEFb is critical for effective reactivation of latent HIV in CD4+ T-cells

ABSTRACT HIV cure strategies that aim to induce viral reactivation for immune clearance leverage latency reversal agents to modulate host pathways which directly or indirectly facilitate viral reactivation. Inhibition of bromo and extra-terminal domain (BET) family member BRD4 reverses HIV latency,...

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Bibliografiska uppgifter

Huvudupphov:	Anne-Marie W. Turner, Frances M. Bashore, Shane D. Falcinelli, Joshua A. Fox, Alana L. Keller, Anthony D. Fenton, Renee F. Geyer, Brigitte Allard, Jennifer L. Kirchherr, Nancie M. Archin, Lindsey I. James, David M. Margolis
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	American Society for Microbiology 2025-04-01
Serie:	Journal of Virology
Ämnen:	BRD4 chemical degraders HIV latency reversal P-TEFb
Länkar:	https://journals.asm.org/doi/10.1128/jvi.01777-24
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