Secondary bile acid lithocholic acid ameliorates colitis-like inflammation in a human intestine-on-chip system

Inflammatory bowel disease is a multifactorial disease of the gastrointestinal tract without curative treatment. Previous studies highlighted that altered fecal bile acid levels correlate with intestinal microbiota composition changes and inflammation in inflammatory bowel disease. Lithocholic acid...

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Principais autores:	Tim Kaden, Manuel Allwang, Johannes Stallhofer, Katja Graf, Martin Raasch, Alexander S. Mosig
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-05-01
coleção:	Frontiers in Immunology
Assuntos:	colitis-on-chip in vitro model inflammatory bowel disease intestine-on-chip lithocholic acid secondary bile acids
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1761539/full
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