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HDACi induces apoptosis of osteosarcoma cells by inhibiting the MAPK pathway

Abstract Investigate the malignant biological effects of the histone deacetylase inhibitor (HDACi) in osteosarcoma (OS) and study the underlying mechanisms through mRNA sequencing. CCK-8, colony formation, Transwell assays, live/dead staining, and flow cytometry were used to observe the malignant bi...

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Principais autores: Chao Qin, Tao-tao Lin, Yi-min Lin, Ye-lei Zhang, Shu-jing Hong, Xiao Jia, Wen-ge Liu
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2026-01-01
Serier:Scientific Reports
Fag:
Osteosarcoma
HDACi
4-PA
MAPK/ERK signaling pathway
Apoptosis
Online adgang:https://doi.org/10.1038/s41598-025-34356-x
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