TAp73 regulates mitochondrial dynamics and multiciliated cell homeostasis through an OPA1 axis

Abstract Dysregulated mitochondrial fusion and fission has been implicated in the pathogenesis of numerous diseases. We have identified a novel function of the p53 family protein TAp73 in regulating mitochondrial dynamics. TAp73 regulates the expression of Optic Atrophy 1 (OPA1), a protein responsib...

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Principais autores:	Niall A. Buckley, Andrew Craxton, Xiao-Ming Sun, Emanuele Panatta, Lucia Giraldez Pinon, Sina Beier, Lajos Kalmar, Jaime Llodrá, Nobuhiro Morone, Ivano Amelio, Gerry Melino, L. Miguel Martins, Marion MacFarlane
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Publishing Group 2024-11-01
Series:	Cell Death and Disease
Acceso en liña:	https://doi.org/10.1038/s41419-024-07130-6
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