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Prolyl Hydroxylase Domain-Containing Protein 3 Gene Expression in Chondrocytes Is Not Essential for Bone Development in Mice

We previously showed that conditional disruption of the <i>Phd2</i> gene in chondrocytes led to a massive increase in long bone trabecular bone mass. Loss of <i>Phd2</i> gene expression or inhibition of PHD2 activity by a specific inhibitor resulted in a several-fold compensatory increase in <i>Phd3...

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Main Authors: Weirong Xing, Sheila Pourteymoor, Gustavo A. Gomez, Yian Chen, Subburaman Mohan
Format: Artigo
Language:Inglês
Published: MDPI AG 2021-08-01
Series:Cells
Subjects:
prolyl hydroxylase
bone development
chondrocyte
bone
gene knockout
Online Access:https://www.mdpi.com/2073-4409/10/9/2200
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