Large-scale manipulation of promoter DNA methylation reveals context-specific transcriptional responses and stability

Abstract Background Cytosine DNA methylation is widely described as a transcriptional repressive mark with the capacity to silence promoters. Epigenome engineering techniques enable direct testing of the effect of induced DNA methylation on endogenous promoters; however, the downstream effects have...

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Principais autores:	Alex de Mendoza, Trung Viet Nguyen, Ethan Ford, Daniel Poppe, Sam Buckberry, Jahnvi Pflueger, Matthew R. Grimmer, Sabine Stolzenburg, Ozren Bogdanovic, Alicia Oshlack, Peggy J. Farnham, Pilar Blancafort, Ryan Lister
格式:	Artigo
語言:	Inglês
出版:	BMC 2022-07-01
叢編:	Genome Biology
主題:	DNA methylation Epigenome engineering CpG islands DNMT Zinc finger Promoter regulation
在線閱讀:	https://doi.org/10.1186/s13059-022-02728-5
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