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Protosappanin B enhances the chemosensitivity of 5-fluorouracil in colon adenocarcinoma by regulating the LINC00612/microRNA-590-3p/Golgi phosphoprotein 3 axis

Abstract Background 5-fluorouracil (5-FU) is conventionally used in chemotherapy for colon adenocarcinomas. Acquired resistance of 5-FU remains a clinical challenge in colon cancer, and efforts to develop targeted agents to reduce resistance have not yielded success. Protosappanin B (PSB), the main...

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Principais autores: Zhongshi Hong, Yachen Li, Mingliang Chen, Xiaojing Chen, Xian Deng, Yuze Wu, Chunxiao Wang, Chengzhi Qiu
Format: Artigo
Sprog:Inglês
Udgivet: Springer 2024-05-01
Serier:Discover Oncology
Fag:
Colon adenocarcinoma
Protosappanin B
LINC00612
miR-590-3p
GOLPH3
Chemoresistance
Online adgang:https://doi.org/10.1007/s12672-024-01036-7
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