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Investigation of the Possible Pharmacologically Active Forms of the Nicotinic Acetylcholine Receptor Agonist Anabaseine

Three major forms of the nicotinic agonist toxin anabaseine (cyclic iminium, cyclic imine and the monocationic open-chain ammonium-ketone) co-exist in almost equal concentrations at physiological pH. We asked the question: Which of these forms is pharmacologically active? First, we investigated the...

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Autores principales: Kristin Andrud, Hong Xing, Bjarne Gabrielsen, Linda Bloom, Vladimir Mahnir, Stephen Lee, Benedict T. Green, Jon Lindstrom, William Kem
Formato: Artigo
Lenguaje:Inglês
Publicado: MDPI AG 2019-10-01
Colección:Marine Drugs
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Acceso en línea:https://www.mdpi.com/1660-3397/17/11/614
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