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Bystander activation of microglia by Brucella abortus-infected astrocytes induces neuronal death via IL-6 trans-signaling

Inflammation plays a key role in the pathogenesis of neurobrucellosis where glial cell interactions are at the root of this pathological condition. In this study, we present evidence indicating that soluble factors secreted by Brucella abortus-infected astrocytes activate microglia to induce neurona...

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Main Authors: Julia Rodríguez, Julia De Santis Arévalo, Vida A. Dennis, Ana M. Rodríguez, Guillermo H. Giambartolomei
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2024-01-01
Series:Frontiers in Immunology
Subjects:
Brucella abortus
neurobrucellosis
astrocytes
microglia
phagocytosis
IL-6
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1343503/full
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