Contribution of BCR-ABL kinase domain mutations to imatinib mesylate resistance in Philadelphia chromosome positive Malaysian chronic myeloid leukemia patients

Development of resistance to imatinib mesylate (IM) in chronic myeloid leukemia (CML) patients is mediated by different mechanisms that can be classified as <em>BCR-ABL</em> dependent or <em>BCR-ABL</em> independent pathways. <em>BCR-ABL</em> dependent mechanisms are most frequently associated with...

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Hlavní autoři:	Marjanu Hikmah Elias, Abdul Aziz Baba, Azlan Husin, Abu Dzarr Abdullah, Rosline Hassan, Goh Ai Sim, S. Fadilah Abdul Wahid, Ravindran Ankathil
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2012-11-01
Edice:	Hematology Reports
Témata:	chronic myeloid leukemia, imatinib mesylate, BCR-ABL dependent mechanisms, tyrosine kinase domain, mutation
On-line přístup:	http://www.pagepress.org/journals/index.php/hr/article/view/4413
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