The IGF-1R Inhibitor NVP-AEW541 Causes Insulin-Independent and Reversible Cardiac Contractile Dysfunction

The antitumor treatment NVP-AEW541 blocks IGF-1R. IGF-1R signaling is crucial for cardiac function, but the cardiac effects of NVP-AEW541 are ill defined. We assessed NVP-AEW541′s effects on cardiac function and insulin response in vivo and in isolated working hearts. We performed a dose–response an...

Cijeli opis

Bibliografski detalji

Glavni autori:	Christina Schenkl, Andrea Schrepper, Estelle Heyne, Torsten Doenst, Michael Schwarzer
Format:	Artigo
Jezik:	Inglês
Izdano:	MDPI AG 2022-08-01
Serija:	Biomedicines
Teme:	NVP-AEW541 small molecule cardiac function cardiac substrate oxidation insulin-like growth factor 1 insulin resistance
Online pristup:	https://www.mdpi.com/2227-9059/10/8/2022
Oznake:	Dodaj oznaku Bez oznaka, Budi prvi tko označuje ovaj zapis!