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Rif1 Regulates the Fate of DNA Entanglements during Mitosis

Clearance of entangled DNA from the anaphase mid-region must accurately proceed in order for chromosomes to segregate with high fidelity. Loss of Taz1 (fission yeast ortholog of human TRF1/TRF2) leads to stalled telomeric replication forks that trigger telomeric entanglements; the resolution of thes...

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Principais autores: Sophie Zaaijer, Nadeem Shaikh, Rishi Kumar Nageshan, Julia Promisel Cooper
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2016-06-01
Serier:Cell Reports
Fag:
telomere
anaphase
chromosome segregation
Rif1
Taz1
ultrafine anaphase bridge
phosphatase
replication fork stalling
Online adgang:http://www.sciencedirect.com/science/article/pii/S2211124716306908
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