Intratumoral injection of IL-12-encoding mRNA targeted to CSFR1 and PD-L1 exerts potent anti-tumor effects without substantial systemic exposure

IL-12 is a potent cytokine for cancer immunotherapy. However, its systemic delivery as a recombinant protein has shown unacceptable toxicity in the clinic. Currently, the intratumoral injection of IL-12-encoding mRNA or DNA to avoid such side effects is being evaluated in clinical trials. In this st...

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Egile Nagusiak:	Claudia Augusta Di Trani, Assunta Cirella, Leire Arrizabalaga, Maite Alvarez, Ángela Bella, Myriam Fernandez-Sendin, Joan Salvador Russo-Cabrera, Celia Gomar, Nuria Ardaiz, Alvaro Teijeira, Elixabet Bolaños, José González-Gomariz, Itziar Otano, Fernando Aranda, Belén Palencia, Aina Segués, Shuyu Huang, Sander M.J. van Duijnhoven, Andrea van Elsas, Ignacio Melero, Pedro Berraondo
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Elsevier 2023-09-01
Saila:	Molecular Therapy: Nucleic Acids
Gaiak:	MT: Delivery Strategies interleukin 12 cancer immunotherapy mRNA locoregional treatment fusion molecule
Sarrera elektronikoa:	http://www.sciencedirect.com/science/article/pii/S2162253123001932
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