Artificial intelligence–enabled multi-omics biomarkers for immune checkpoint blockade: mechanisms, predictive modeling, and clinical translation

Immune checkpoint inhibitors (ICIs) have transformed oncology, yet durable benefit remains confined to a minority of patients, revealing the limitations of single biomarkers such as PD-L1 expression, tumor mutational burden, and microsatellite instability. Multi-omics profiling, spanning genomics, t...

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Автори:	Xiaodong Wang, Di Xiong, Songli Cui, Bingchen Duan, Gouping Ding, Yiping Huang, Qianqian Wang
Формат:	Artigo
Мова:	Inglês
Опубліковано:	Frontiers Media S.A. 2026-02-01
Серія:	Frontiers in Immunology
Предмети:	artificial intelligence biomarkers cancer immunotherapy multi-omics
Онлайн доступ:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1732079/full
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