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Frequency of thiopurine methyltransferase variants and exploratory predictors of azathioprine-induced leukopenia in Saudi patients with inflammatory bowel disease

Background: Azathioprine, a common inflammatory bowel disease (IBD) treatment, carries a myelosuppression risk, particularly leukopenia. Thiopurine methyltransferase (TPMT) genotyping can predict azathioprine-induced leukopenia (AIL), but data on TPMT polymorphisms in Saudi IBD patients are scarce....

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Principais autores: Yaser K. Meeralam, Adnan. B. Al-Zanbagi, Mona Al Saedi, Mohammed Sulaimani, Abdulrahman Basfar, Wafi Almutawa, Sayeda H. Albelewi, Mohammed K. Shariff
Formato: Artigo
Idioma:Inglês
Publicado em: Wolters Kluwer Medknow Publications 2026-01-01
coleção:The Saudi Journal of Gastroenterology
Assuntos:
azathioprine
inflammatory bowel disease
leukopenia
pharmacogenomics
saudi arabia
thiopurine methyltransferase
tpmt genotyping
Acesso em linha:https://journals.lww.com/10.4103/sjg.sjg_195_25
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