In vitro and in vivo neurotoxicity of prion protein oligomers.
The mechanisms underlying prion-linked neurodegeneration remain to be elucidated, despite several recent advances in this field. Herein, we show that soluble, low molecular weight oligomers of the full-length prion protein (PrP), which possess characteristics of PrP to PrPsc conversion intermediates...
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| Главные авторы: | , , , , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Public Library of Science (PLoS)
2007-08-01
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| Серии: | PLoS Pathogens |
| Online-ссылка: | http://europepmc.org/articles/PMC1959381?pdf=render |
| Метки: |
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