Hibernating bear serum triggers an anti-fibrotic signature in human fibroblasts, involving ECM remodeling and MAPK signaling activation

Abstract Some hibernating species, such as the brown bear (Ursus arctos), can endure several months of physical inactivity and fasting without suffering the typical deterioration observed in inactive or starved non-hibernators, such as muscle atrophy, bone loss or systemic inflammation. The underlyi...

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Autori principali:	Jade Sutter, Alexandre Geffroy, Amandine Moretton, Anne Randi Græsli, Jonas Kindberg, Lydie Combaret, Etienne Lefai, Isabelle Garreau-Balandier, Fabrice Bertile, Patrick Vernet
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2026-03-01
Serie:	Scientific Reports
Soggetti:	Extracellular matrix Fibrosis Phosphorylation Signaling Fibroblast
Accesso online:	https://doi.org/10.1038/s41598-026-43734-y
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