A CLC-ec1 mutant reveals global conformational change and suggests a unifying mechanism for the CLC Cl–/H+ transport cycle

Among coupled exchangers, CLCs uniquely catalyze the exchange of oppositely charged ions (Cl– for H+). Transport-cycle models to describe and explain this unusual mechanism have been proposed based on known CLC structures. While the proposed models harmonize with many experimental findings, gaps and...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Tanmay S Chavan, Ricky C Cheng, Tao Jiang, Irimpan I Mathews, Richard A Stein, Antoine Koehl, Hassane S Mchaourab, Emad Tajkhorshid, Merritt Maduke
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	eLife Sciences Publications Ltd 2020-04-01
Σειρά:	eLife
Θέματα:	antiporter membrane exchanger crystallography MD simulations DEER spectroscopy chloride
Διαθέσιμο Online:	https://elifesciences.org/articles/53479
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