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Structural dynamics of E. coli single-stranded DNA binding protein reveal DNA wrapping and unwrapping pathways

Escherichia coli single-stranded (ss)DNA binding (SSB) protein mediates genome maintenance processes by regulating access to ssDNA. This homotetrameric protein wraps ssDNA in multiple distinct binding modes that may be used selectively in different DNA processes, and whose detailed wrapping topologi...

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Principais autores: Sukrit Suksombat, Rustem Khafizov, Alexander G Kozlov, Timothy M Lohman, Yann R Chemla
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2015-08-01
Serier:eLife
Fag:
single stranded DNA binding protein
optical tweezer
energy landscape
protein-nucleic acid interaction
single molecule
Online adgang:https://elifesciences.org/articles/08193
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