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Nucleolin-aptamer therapy in retinoblastoma: molecular changes and mass spectrometry–based imaging

Retinoblastoma (RB) is an intraocular childhood tumor which, if left untreated, leads to blindness and mortality. Nucleolin (NCL) protein which is differentially expressed on the tumor cell surface, binds ligands and regulates carcinogenesis and angiogenesis. We found that NCL is over expressed in R...

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Principais autores: Nithya Subramanian, Amitava Srimany, Jagat R Kanwar, Rupinder K Kanwar, Balachandran Akilandeswari, Pukhraj Rishi, Vikas Khetan, Madavan Vasudevan, Thalappil Pradeep, Subramanian Krishnakumar
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016-01-01
coleção:Molecular Therapy: Nucleic Acids
Assuntos:
cancer therapy
DESI MS imaging
nucleolin aptamer
retinoblastoma xenograft
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2162253117300793
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