A Study of 3-Substituted 7-Methoxy-2,3,4,5-tetrahydro-1<i>H</i>-benzo[<i>d</i>]azepin-1-ols Leading to Candidate PET Radioligands for Imaging Brain GluN2B: Design, Synthesis, and Structure–Activity Relationships

<i>N</i>-Methyl-D-aspartate (NMDA) receptors are ligand- and voltage-gated ion channels essential for synaptic plasticity, learning, and memory. The GluN2B subunit, highly expressed in the forebrain and spinal cord, is implicated in multiple neurological and psychiatric disorders, making it an attra...

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Autori principali:	Lisheng Cai, Leah Noelle Millard, Sean Wallace Costner, Alyssa Wang, Yonglan Liu, Victor William Pike
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	MDPI AG 2026-05-01
Serie:	Molecules
Soggetti:	GluN2B NMDA receptor structure–activity relationship radioligand PET
Accesso online:	https://www.mdpi.com/1420-3049/31/9/1541
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