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Optimization of mucosal responses after intramuscular immunization with integrase defective lentiviral vector.

Many infectious agents infiltrate the host at the mucosal surfaces and then spread systemically. This implies that an ideal vaccine should induce protective immune responses both at systemic and mucosal sites to counteract invasive mucosal pathogens. We evaluated the in vivo systemic and mucosal ant...

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Библиографические подробности
Главные авторы: Alessandra Rossi, Zuleika Michelini, Pasqualina Leone, Martina Borghi, Maria Blasi, Roberta Bona, Massimo Spada, Felicia Grasso, Alessio Gugliotta, Mary E Klotman, Andrea Cara, Donatella Negri
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science (PLoS) 2014-01-01
Серии:PLoS ONE
Online-ссылка:http://europepmc.org/articles/PMC4161417?pdf=render
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