Mepolizumab alters gene regulatory networks of nasal airway type-2 and epithelial inflammation in urban children with asthma

Abstract Mepolizumab (anti-IL5 therapy) reduces asthma exacerbations in urban children with exacerbation-prone eosinophilic asthma. We previously utilized nasal transcriptomics to identify inflammatory pathways (gene co-expression modules) associated with asthma exacerbations despite this therapy. I...

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Autori principali:	Courtney L. Gaberino, R. Max Segnitz, Kimberly A. Dill-McFarland, Leonard B. Bacharier, Agustin Calatroni, Michelle A. Gill, Jeffrey Stokes, Andrew H. Liu, Robyn T. Cohen, Rajesh Kumar, Abigail Lang, Gurjit K. Khurana Hershey, Michael G. Sherenian, Edward M. Zoratti, Stephen J. Teach, Meyer Kattan, Patrice M. Becker, Alkis Togias, William W. Busse, Daniel J. Jackson, Matthew C. Altman
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2025-09-01
Serie:	Nature Communications
Accesso online:	https://doi.org/10.1038/s41467-025-63629-2
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