Perspectives of autophagy-tethering compounds (ATTECs) in drug discovery

Degrader technologies provide unprecedented strategies to tackle diseases caused by pathogenic proteins that are difficult to target by the traditional inhibitor approach. One pioneering technology, proteolysis-targeting chimera (PROTAC), has revolutionized small-molecule drug discovery. However, PR...

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Detalhes bibliográficos

Principais autores:	Yu Ding, Dong Xing, Yiyan Fei, Shouqing Luo, Boxun Lu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	KeAi Communications Co., Ltd. 2024-03-01
coleção:	Medicine Plus
Assuntos:	Autophagy Degrader Targeted degradation Drug discovery High-throughput screening LC3
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S295034772300004X
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