Feasibility of IG and TCR rearrangements quantification in ctDNA for monitoring clinical response in pediatric lymphomas

IntroductionLymphomas are malignancies of the lymphatic system characterized by clonal rearrangements of immunoglobulin (Ig) and T-cell receptor (TCR) genes. While diagnosis relies on tissue biopsy, circulating tumor DNA (ctDNA) analysis offers a minimally invasive approach for real-time disease mon...

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Principais autores:	Milena R. Marusco, Rudolph R. Vera, Caroline de O. Lopes, Natacha A. Migita, Dieila G. De Lima, Felipe L. T. Silva, Guilherme N. N. Giusti, João Meidanis, Camila M. M. Daiggi, Camila Z. Mouco, José A. Yunes, Mariana C. Maschietto, Patricia Y. Jotta
Formato:	Artigo
Idioma:	Inglês
Publicado:	Frontiers Media S.A. 2026-06-01
Series:	Frontiers in Genetics
Assuntos:	ctDNA (circulating tumor DNA) ig/TCR gene rearrangements liquid biopsy minimal residual disease (MRD) pediatric lymphoma
Acceso en liña:	https://www.frontiersin.org/articles/10.3389/fgene.2026.1875204/full
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