A bispecific nanobody dimer broadly neutralizes SARS-CoV-1 & 2 variants of concern and offers substantial protection against Omicron via low-dose intranasal administration

Abstract Current SARS-CoV-2 Omicron subvariants impose a heavy burden on global health systems by evading immunity from most developed neutralizing antibodies and vaccines. Here, we identified a nanobody (aSA3) that strongly cross-reacts with the receptor binding domain (RBD) of both SARS-CoV-1 and...

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Bibliografische Detailangaben

Hauptverfasser:	Huan Ma, Xinghai Zhang, Weihong Zeng, Junhui Zhou, Xiangyang Chi, Shaohong Chen, Peiyi Zheng, Meihua Wang, Yan Wu, Dan Zhao, Fanwu Gong, Haofeng Lin, Hancong Sun, Changming Yu, Zhengli Shi, Xiaowen Hu, Huajun Zhang, Tengchuan Jin, Sandra Chiu
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 2022-12-01
Schriftenreihe:	Cell Discovery
Online-Zugang:	https://doi.org/10.1038/s41421-022-00497-w
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