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Advancing liver cancer treatment with dual-targeting CAR-T therapy

Abstract Chimeric antigen receptor (CAR)-T cell therapy targeting glypican-3 (GPC3) has shown promise in the treatment of hepatocellular carcinoma (HCC). However, the efficacy of CAR-T cells that focus solely on cell surface tumor-associated antigens is often limited. To overcome this challenge, we...

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Autori principali: Ze Yang, Chao Cheng, Zhongliang Li, Huajing Wang, Mengmei Zhang, Ermin Xie, Xu He, Bing Liu, Hongwei Sun, Jiantao Wang, Xiaopei Li, Dingjie Liu, Xiaowen Lin, Xianyang Li, Ping Jiang, Ligong Lu, Xiaowen He, Meixiao Zhan, Ke He, Wei Zhao
Natura: Artigo
Lingua:Inglês
Pubblicazione: BMC 2025-06-01
Serie:Journal of Nanobiotechnology
Soggetti:
Liver cancer
Glypican-3
Alpha-fetoprotein
CAR-T
BiTE
Accesso online:https://doi.org/10.1186/s12951-025-03512-w
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