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PU.1 Is Required for the Developmental Progression of Multipotent Progenitors to Common Lymphoid Progenitors

The transcription factor PU.1 is required for the development of mature myeloid and lymphoid cells. Due to this essential role and the importance of PU.1 in regulating several signature markers of lymphoid progenitors, its precise function in early lymphopoiesis has been difficult to define. Here, w...

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Principais autores: Swee Heng Milon Pang, Carolyn A. de Graaf, Douglas J. Hilton, Nicholas D. Huntington, Sebastian Carotta, Li Wu, Stephen L. Nutt
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2018-06-01
Serier:Frontiers in Immunology
Fag:
PU.1
transcription factor
multipotent progenitor
common lymphoid progenitor
Rag1
Online adgang:https://www.frontiersin.org/article/10.3389/fimmu.2018.01264/full
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