PGC-1α-mediated imbalance of mitochondria-lipid droplet homeostasis in neomycin-induced ototoxicity and nephrotoxicity

Ototoxicity and nephrotoxicity are the most prevalent side effects of aminoglycoside antibiotics (gentamicin, amikacin, neomycin) and platinum anti-tumor drugs (cisplatin, carboplatin). The inner ear and kidney share similarities in drug deposition and toxicity, but the underlying pathophysiological...

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Autori principali:	Bin Chen, Cheng Cheng, Yunhao Wu, Siyu Li, Mo Han, Le Zhen, Ying Peng, Suhan Guo, Kaidi Shen, Xia Gao, Renjie Chai, Guangji Wang, Fang Zhou
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2024-10-01
Serie:	Acta Pharmaceutica Sinica B
Soggetti:	Mitochondria Neomycin Nephrotoxicity Ototoxicity Lipid metabolism Triacylglycerol
Accesso online:	http://www.sciencedirect.com/science/article/pii/S221138352400217X
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