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Gasdermin E is dispensable for H1N1 influenza virus pathogenesis in mice

ABSTRACT Targeting cell death pathways, including pyroptosis and necroptosis, has been shown to mitigate influenza virus infection severity. Here, we examined whether pyroptosis specifically driven by the pore-forming protein gasdermin E (GSDME) is involved in regulating influenza virus infection ou...

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Autori principali: Samuel Speaks, Jonathan Papa, Matthew McFadden, Jack E. Roettger, Benjamin D. Liu, Shreenath Mohan, Brendan M. Reznik, Steve Leumi, Jana M. Cable, Adriana Forero, Jacob S. Yount
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2026-03-01
Serie:Microbiology Spectrum
Soggetti:
gasdermin E
influenza virus
pyroptosis
Accesso online:https://journals.asm.org/doi/10.1128/spectrum.02472-25
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