17ß-Estradiol regulates mTORC2 sensitivity to rapamycin in adaptive cardiac remodeling.

Adaptive cardiac remodeling is characterized by enhanced signaling of mTORC2 downstream kinase Akt. In females, 17ß-estradiol (E2), as well as Akt contribute essentially to sex-related premenopausal cardioprotection. Pharmacologic mTOR targeting with rapamycin is increasingly used for various clinic...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Angelika Kusch, Maria Schmidt, Dennis Gürgen, Daniel Postpieszala, Rusan Catar, Björn Hegner, Merci M Davidson, Shokoufeh Mahmoodzadeh, Duska Dragun
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2015-01-01
coleção:	PLoS ONE
Acesso em linha:	http://europepmc.org/articles/PMC4399939?pdf=render
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!