Small-molecule inhibition of the METTL3/METTL14 complex suppresses neuroblastoma tumor growth and promotes differentiation

Summary: The N6-methyladenosine (m6A) RNA modification is an important regulator of gene expression. m6A is deposited by a methyltransferase complex that includes methyltransferase-like 3 (METTL3) and methyltransferase-like 14 (METTL14). High levels of METTL3/METTL14 drive the growth of many types o...

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Κύριοι συγγραφείς:	Monica Pomaville, Mohansrinivas Chennakesavalu, Pingluan Wang, Zhiwei Jiang, Hui-Lung Sun, Peizhe Ren, Ryan Borchert, Varsha Gupta, Chang Ye, Ruiqi Ge, Zhongyu Zhu, Mallory Brodnik, Yuhao Zhong, Kelley Moore, Helen Salwen, Rani E. George, Malgorzata Krajewska, Alexandre Chlenski, Mark A. Applebaum, Chuan He, Susan L. Cohn
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Elsevier 2024-05-01
Σειρά:	Cell Reports
Θέματα:	CP: Cancer
Διαθέσιμο Online:	http://www.sciencedirect.com/science/article/pii/S2211124724004935
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