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First-In-Class Inhibitors Targeting the Interaction between Bacterial RNA Polymerase and Sigma Initiation Factor Affect the Viability and Toxin Release of <i>Streptococcus pneumoniae</i>

Novel antimicrobial classes are in desperate need for clinical management of infections caused by increasingly prevalent multi-drug resistant pathogens. The protein-protein interaction between bacterial RNA polymerase (RNAP) and the housekeeping sigma initiation factor is essential to transcription...

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Autori principali: Jiqing Ye, Adrian Jun Chu, Lin Lin, Xiao Yang, Cong Ma
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2019-08-01
Serie:Molecules
Soggetti:
RNA polymerase
sigma factor
transcription
inhibitor
antimicrobial discovery
Accesso online:https://www.mdpi.com/1420-3049/24/16/2902
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