Flat dose intravenous immunoglobulin primary infection prophylaxis in multiple myeloma patients on BCMA and GPRC5D bispecific antibody therapy: the Vanderbilt experience

Bispecific antibodies (BsAbs) can cause profound hypogammaglobulinemia. Conventional infection prophylaxis has utilized weight-based IVIG dosing. However, the use of flat IVIG dosing can significantly reduce IVIG utilization. We evaluated hypogammaglobulinemia and infection risk in relapsed/refracto...

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Asıl Yazarlar:	Naimisha Marneni, Spencer Lessans, Bhagirathbhai Dholaria, Salyka Sengsayadeth, Eden A. Biltibo, Vivek Patel, Shakthi Bhaskar, Reena Jayani, Sanjay Mohan, Ashwin Kishtagari, David Morgan, Olalekan O. Oluwole, Bipin N. Savani, Adetola A. Kassim, Muhamed Baljevic
Materyal Türü:	Artigo
Dil:	Inglês
Baskı/Yayın Bilgisi:	Frontiers Media S.A. 2026-02-01
Seri Bilgileri:	Frontiers in Immunology
Konular:	bispecific antibodies (BsAbs) cellular therapies hypogammaglobinemia IVIG (intravenous immunoglobulin) administration multiple myeloma
Online Erişim:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1721820/full
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