NF-κB System Is Chronically Activated and Promotes Glomerular Injury in Experimental Type 1 Diabetic Kidney Disease

High glucose concentration can activate TLR4 and NF-κB, triggering the production of proinflammatory mediators. We investigated whether the NF-κB pathway is involved in the pathogenesis and progression of experimental diabetic kidney disease (DKD) in a model of long-term type 1 diabetes mellitus (DM...

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Autors principals:	Orestes Foresto-Neto, Amanda Helen Albino, Simone Costa Alarcon Arias, Viviane Dias Faustino, Fernanda Florencia Fregnan Zambom, Marcos Antonio Cenedeze, Rosilene Motta Elias, Denise Maria Avancini Costa Malheiros, Niels Olsen Saraiva Camara, Clarice Kazue Fujihara, Roberto Zatz
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2020-02-01
Col·lecció:	Frontiers in Physiology
Matèries:	diabetic kidney disease glomerulosclerosis NF-κB innate immunity pyrrolidine dithiocarbamate
Accés en línia:	https://www.frontiersin.org/article/10.3389/fphys.2020.00084/full
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