Anti-Tumor Activity of AZD4547 Against NTRK1 Fusion Positive Cancer Cells Through Inhibition of NTRKs

Inhibitors of tropomyosin-related kinases (TRKs) display remarkable outcomes in the regression of cancers harboring the Neurotrophin Receptors Tyrosine Kinase (NTRK) fusion gene. As a result, TRKs have become attractive targets in anti-cancer drug discovery programs. Here, we demonstrate that AZD454...

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Principais autores:	Hanna Cho, Namkyoung Kim, Takashi Murakami, Taebo Sim
格式:	Artigo
语言:	Inglês
出版:	Frontiers Media S.A. 2021-11-01
丛编:	Frontiers in Oncology
主题:	drug repositioning AZD4547 NTRK fusion NTRK inhibitor colorectal cancer Ba/F3 TRK
在线阅读:	https://www.frontiersin.org/articles/10.3389/fonc.2021.757598/full
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