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Immune tolerance promotion by LSEC-specific lentiviral vector-mediated expression of the transgene regulated by the stabilin-2 promoter

Liver sinusoidal endothelial cells (LSECs) are specialized endocytic cells that clear the body from blood-borne pathogens and waste macromolecules through scavenger receptors (SRs). Among the various SRs expressed by LSECs is stabilin-2 (STAB2), a class H SR that binds to several ligands, among whic...

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Huvudupphov: Ester Borroni, Chiara Borsotti, Roberta A. Cirsmaru, Vakhtang Kalandadze, Rosella Famà, Simone Merlin, Brian Brown, Antonia Follenzi
Materialtyp: Artigo
Språk:Inglês
Utgiven: Elsevier 2024-03-01
Serie:Molecular Therapy: Nucleic Acids
Ämnen:
MT: Delivery Strategies
LSECs
immune tolerance
gene therapy
liver
transgene expression
Länkar:http://www.sciencedirect.com/science/article/pii/S2162253124000039
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