Combinatorial efficacy of entospletinib and chemotherapy in patient-derived xenograft models of infant acute lymphoblastic leukemia

Survival of infants with KMT2A-rearranged (R) acute lymphoblastic leukemia (ALL) remains dismal despite intensive chemotherapy. We observed constitutive phosphorylation of spleen tyrosine kinase (SYK) and associated signaling proteins in infant ALL patient-derived xenograft (PDX) model specimens and...

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Detalhes bibliográficos

Principais autores:	Joseph P. Loftus, Anella Yahiaoui, Patrick A. Brown, Lisa M. Niswander, Asen Bagashev, Min Wang, Allyson Schauf, Stacey Tannheimer, Sarah K. Tasian
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Ferrata Storti Foundation 2020-05-01
coleção:	Haematologica
Acesso em linha:	https://haematologica.org/article/view/9755
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