Learning from failure - rationale and design for a study about discontinuation of randomized trials (DISCO study)

<p>Abstract</p> <p>Background</p> <p>Randomized controlled trials (RCTs) may be discontinued because of apparent harm, benefit, or futility. Other RCTs are discontinued early because of insufficient recruitment. Trial discontinuation has ethical implications, because participants consent on the prem...

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Prif Awduron:	Kasenda Benjamin, von Elm Erik B, You John, Blümle Anette, Tomonaga Yuki, Saccilotto Ramon, Amstutz Alain, Bengough Theresa, Meerpohl Jörg, Stegert Mihaela, Tikkinen Kari A O, Neumann Ignacio, Carrasco-Labra Alonso, Faulhaber Markus, Mulla Sohail, Mertz Dominik, Akl Elie A, Bassler Dirk, Busse Jason W, Ferreira-González Ignacio, Lamontagne Francois, Nordmann Alain, Rosenthal Rachel, Schandelmaier Stefan, Sun Xin, Vandvik Per O, Johnston Bradley C, Walter Martin A, Burnand Bernard, Schwenkglenks Matthias, Bucher Heiner C, Guyatt Gordon H, Briel Matthias
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	BMC 2012-08-01
Cyfres:	BMC Medical Research Methodology
Pynciau:	Randomized controlled trial Trial discontinuation Slow recruitment Ethics committees Trial protocols
Mynediad Ar-lein:	http://www.biomedcentral.com/1471-2288/12/131
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