Rett-causing mutations reveal two domains critical for MeCP2 function and for toxicity in MECP2 duplication syndrome mice

Loss of function of the X-linked gene encoding methyl-CpG binding protein 2 (MeCP2) causes the progressive neurological disorder Rett syndrome (RTT). Conversely, duplication or triplication of Xq28 causes an equally wide-ranging progressive neurological disorder, MECP2 duplication syndrome, whose fe...

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Bibliographic Details

Main Authors:	Laura Dean Heckman, Maria H Chahrour, Huda Y Zoghbi
Format:	Artigo
Language:	Inglês
Published:	eLife Sciences Publications Ltd 2014-06-01
Series:	eLife
Subjects:	MeCP2 Rett syndrome MECP2 duplication syndrome neurobiology genetic
Online Access:	https://elifesciences.org/articles/02676
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