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Multiple myeloma risk linked to DNA damage response genes

Abstract Background DNA damage response genes (DDRG), implicated in several cancers as both predisposing risk factors as well as biomarkers for aggressiveness, have not been fully explored in multiple myeloma (MM). Methods Herein, we analyzed disease associations of pathogenic variations in nine put...

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Hlavní autoři: Michael Conry, Irina Ostrovnaya, Yelena Kemel, Saloni Sinha, Linda B. Baughn, Brian Avery, Kylee Maclachlan, Victoria Groner, Lauren Banaszak, Aaron Norman, Nicholas J. Boddicker, Alyssa Clay-Gilmour, Shaji Kumar, Ellen Kim, Sita Dandiker, Mitul Waghmare, Susan Slager, Douglas W. Sborov, Judy Garber, Elizabeth E. Brown, Michelle Hildebrandt, Parameshwaran Hari, Nicola Camp, Celine Vachon, Saad Usmani, Kenneth Offit, Vijai Joseph
Médium: Artigo
Jazyk:Inglês
Vydáno: BMC 2026-01-01
Edice:Journal of Hematology & Oncology
Témata:
Cancer genetics
Cancer Prevention
Genetic Risk Factors
Germline Predisposition
Plasma Cell Neoplasms
Rare Pathogenic Variants
On-line přístup:https://doi.org/10.1186/s13045-025-01776-1
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